个人简述:

主持国家自然科学基金（脂肪细胞通过CCR2-CCL2生物学轴促进乳腺癌转移与上皮-间质转化的作用与机制研究）、江苏省自然科学基金（基于CCR5受体-配体相互作用的SN0883抗肿瘤作用及机制研究）、教育部博士点基金（脂肪细胞通过CC型趋化因子受体5促进乳腺癌细胞转移的作用及机制研究）等课题；作为主要成员参与多项863项目、重大专项、国家自然科学基金等的研究工作。

科研工作:

近5年代表论文：1. Lin SS, Wan SY, Sun L, Hu JL, Fang DD, Zhao R, et al. Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia. Cancer Sci. (In Rivision) (IF 3.84)2. Lin S, Sun L, Hu J, Wan S, Zhao R, Yuan S, et al. Chemokine C-X-C motif receptor 6 contributes to cell migration during hypoxia. Cancer Lett. 2009 279(1): 108-17. (IF 4.86)3. Lin SS, Sun L, Zhang YK, Zhao RP, Liang WL, Yuan ST, et al. Topotecan inhibits cancer cell migration by down-regulation of chemokine CC motif receptor 7 and matrix metalloproteinases. Acta Pharmacol Sin. 2009 30(5): 628-36. (IF 1.90)4. Fang DD, Sun L, Lin SS, Zhou LQ, Su N, Yuan ST, et al. Vinorelbine inhibits angiogenesis and 95D migration induced by hypoxic fibroblasts. J Cell Biochem. (In Press) (IF 3.12)5. Zhou L, Sun L, Lin S, Fang D, Zhao R, Zhu J, et al. Inhibition of angiogenic activity of hypoxic fibroblast cell line MRC-5 in vitro by topotecan. Med Oncol. 2010 Nov 9. (IF 2.21)6. Sun L, Lin S, Zhao R, Yu B, Yuan S, Zhang L. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor. Biol Pharm Bull. 2010 33(7): 1192-8. (IF 1.81)7. Liu J, Jiang Z, Xiao J, Zhang Y, Lin S, Duan W, et al. Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines. Phytomedicine 2009 (11): 1006-13. (IF 2.66)8. Yu J, Guo QL, You QD, Lin SS, Li Z, Gu HY, et al. Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells. Cancer Chemother Pharmacol. 2006 58(4): 434-43. (IF 2.62)9. Guo QL, Lin SS, You QD, Gu HY, Yu J, Zhao L, et al. Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. Life Sci. 2006 78(11): 1238-45. (IF 2.45)

教育背景:

2005年中国药科大学药理学专业硕士研究生毕业，2008年中国药科大学药理学专业博士研究生毕业，后赴美国纽约州立大学布法罗分校药学系从事博士后研究。