个人简述:

现任中国药科大学新药筛选中心副研究员。作为主要成员参与国家“十五”重大专项“新药筛选平台技术研究、国家“十五”重大专项“新型高通量筛选模型、化合物库建设和药物筛选”、国家“十一五”科技重大专项“新药筛选核心技术规范化平台建设及其科学应用”的研究，还承担多项国家自然科学基金和省部级科研项目。已发表论文70余篇，其中SCI论文50余篇，参编英文专著1部；申请专利10项，其中获得授权专利1项。

科研工作:

代表性论文：1. Jun Liu, Ying Yuan, Wenna Chen, Juan Putra, Arief A. Suriawinata, Austin D. Schen, Halli Miller, Indira Guleria, Richard J. Barth, Yina H. Huang, Li Wang. Non-redundant regulation of murine T cell responses by VISTA and PD-1 immune-checkpoints. PNAS 2015, 112 (21): 6682-66873. (IF 9.674)2. Li Wang, Isabella Le Mercier, Juan Putra, Wenna Chen, Jun Liu, et al. Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. PNAS 2014, 111(41): 14846-51. (IF 9.674)3. Xue Wang, Yupeng Chen, Daoud Waseem Hassan, Hongbin Sun, Jun Liu*. Combination Therapy with Oleanolic Acid and Metformin as a Synergistic Treatment for Diabetes. Journal of Diabetes Research. 2015, doi: 10.1155/2015/973287. (IF 2.164)4. Xue Wang, Qian Lu, Dongsheng Yu, Yupeng Chen, Jing Shang, Luyong Zhang, Hongbin Sun, Jun Liu*. Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model. Chinese Journal of Natural Medicines 2015, 13(7): 0529−0534. (IF 1.114)5. Jun Liu, Xue Wang, Yupeng Chen, Lifei Mao, Jing Shang, Hongbin Sun*, Luyong Zhang*. Maslinic acid modulates glycogen metabolism by enhancing the insulin signaling pathway and inhibiting glycogen phosphorylase. Chinese Journal of Natural Medicines 2014，12 (4): 0259−0265. (IF 1.114)6. Liying, Zhang, Xiaojian Jia, Jizhe Dong, Dongyin Chen, Jun Liu*, Luyong Zhang, Xiaoan Wen*. Synthesis and Evaluation of Novel Oleanolic Acid Derivatives as Potential Antidiabetic Agents. Chemical Biology & Drug Design 2014, 83, 297-305. (IF 2.485)7. Liying Zhang, Yingxia Zhang, Jizhe Dong, Jun Liu*, Luyong Zhang, Hongbin Sun*. Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid. Bioorganic & Medicinal Chemistry Letters 2012, 22, 1036-1039. (IF 2.420)8. Lei Zhang, Xiaojie Chen, Jun Liu, Qingzhang Zhu, Ying Leng, Xiaomin Luo, Hualiang Jiang, Hong Liu*. Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase. European journal of medicinal chemistry 2012, 58, 624-639. (co-first author) (IF 3.447)9. Jun Liu, Ting He, Qian Lu, Jing Shang, HB Sun, Luyong Zhang. Asiatic acid preserves beta mass and mitigates hyperglycemia in streptozocin-induced diabetic rats. Diabetes Metabolism Research and Reviews 2010, 26, 448-454. (IF 3.553)10. Jun Liu, Hongbin Sun, Weigang Duan, Luyong Zhang. Maslinic acid reduces blood glucose and body weight in KK-Ay mice. Biological & Pharmaceutical Bulletin 2007, 30, 2075-2078. (IF 1.828)11. Gary A. Visner, Fuhua Lu, Hailan Zhou, Jun Liu, Kristy Kazemfar, and Anupam Agarwal. Rapamycin Induces Heme Oxygenase-1 in Human Pulmonary Vascular Cells: Implications in the Antiproliferative Response to Rapamycin. Circulation 2003, 107, 911–916. (IF 14.430)

教育背景:

1994年7月获中国药科大学中药药理专业学士学位；1995-1996年在中科院上海药物所药理室任研究助理；1998-2001年在美国佛罗里达大学医学院任研究助理，从事分子生物学研究；2003年获美国加州州立大学生物化学硕士学位；2011年获中国药科大学药理学专业博士学位；2014年1月至2015年2月先后在美国Dartmouth学院和Wisconsin医学院进行访问学者交流，从事肿瘤免疫学研究。