个人简述:

从事胚胎干细胞（ESC）染色体结合蛋白对干细胞分化、凋亡的转录调控研究。主要学术贡献：1、在全基因组水平对p53在ESCs中的线性转录调控网络进行了逐步深入的研究（PNAS， IF： 9.423; Molecular Cell, IF：13.958），首次揭示了p53调控ESCs分化的双重作用2、发现了由p53调控的lncRNA Apela以及hnRNPL与p53构成的负反馈调控环在ESCs细胞凋亡过程中的调控机制（Cell Stem Cell， IF: 22.387）。代表性论文：1. Li M, ..., Huang J. (2015) An Apela RNA-Containing Negative Feedback Loop Regulates p53- Mediated Apoptosis in Embryonic Stem Cells. Cell Stem Cell 16, 669-6832. Li M, ..., Huang J. (2012) Distinct regulatory mechanisms and functions of p53-activated and p53-repressed DNA damage response genes in embryonic stem cells. Molecular Cell 46, 1-133. Li M, ... Huang J. (2012) Genome-wide studies of the transcriptional regulation by p53. BBA 1819, 684-6874. Lee KH*, Li M*, Michalowski AM*, ..., Huang J (2009) A genome-wide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. PNAS 107, 69-74 (Co-first author)

科研工作:

1. Li M, ..., Huang J. (2015) Cell Stem Cell 16, 669-683（IF=23.394）2. Li M, ..., Huang J. (2012) Molecular Cell 46, 1-13（IF=14.714）3. Lee KH*, Li M*, Michalowski AM*, ..., Huang J (2009) PNAS 107, 69-74 (Co-first author) （IF=9.661）