个人简述:

吴旭日，男，博士，副教授，硕士研究生导师。现为中国药科大学生命科学与技术学院副教授，主要从事酶学、抗生素生物合成机制和药物合成生物学等方面的研究工作。讲授本科生《生物化学》和《生物化学与分子生物学》等课程。入选江苏省第十四批“六大人才高峰”B类和江苏高校“青蓝工程”优秀青年骨干教师等人才计划。迄今共发表SCI论文22篇，申请PCT和中国发明专利11项，其中获授权3项。现主持“重大新药创制”国家科技重大专项项目、国家自然科学基金和教育部博士点新教师基金等多项基金课题，参与多项国家级和省部级科研项目。

科研工作:

近5年发表的文章：[1]Gu, Y.Y., 1Wu, X.R.,1 Liu, H., Pan, Q. & Chen Y.J.* Photoswitchable heparinase III for enzymatic preparation of low molecular weight heparin. Org. Lett. 2018, 20(1): 48-51. (IF = 6.579)[2] Wu, X.R., Jin, L., Zhang, H., Tong, R.N., Ma, M. & Chen, Y.J.* Identification of truncated form of NosP as a transcription factor to regulate the biosynthesis of nosiheptide.FASEB J. 2018, 32(1): 453-465. (IF = 5.498) [3] Jin L.1, Wu X.R.1, Xue Y.J., Jin Y., Wang S.Z., Chen, Y.J.* Mutagenesis of NosM leader peptide reveals important elements in nosiheptide biosynthesis. Appl. Environ. Microbiol., 2017, 83: e02880-16. (IF = 3.823) 共同一作[4] Gu Y.Y., Lu M.L.,Wang Z.Q., Wu X.R.*, Chen Y.J.* Expanding the catalytic promiscuity of heparinase III from Pedobacter heparinus.Chem.-Eur. J., 2017, 23: 2548-2551. (IF = 5.771) [5] Wu X.R., Huang P.Y., Xue Y.J., Liu W.Y., Ma M., Chen Y.J.* The catalytic characteristics of NocB in nocathiacin biosynthesis from Nocardia sp. ATCC 202099. RSC Adv., 2016, 6(76), 72399-72408. (IF = 3.289) [6]Wu X.R., Zhu S.R., Huang P.Y., Chen Y.J.* Highly specific quantification of microRNA by coupling probe-rolling circle amplification and Förster resonance energy transfer. Anal Biochem., 2016, 502, 16-23. (IF = 2.243) [7] Wu X.R., Gou X.D., Chen Y.J.* Enzymatic preparation of t-butyl-6-cyano- (3R,5R)-dihydroxyhexanoate by a whole-cell biocatalyst co-expressing carbonyl reductase and glucose dehydrogenase. Process Biochem., 2015, 50: 104-110. (IF = 2.516)[8] Wu X.R., Fei M.D., Chen Y., Wang Z.Q., Chen Y.J.* Enzymatic synthesis of L-norephedrine by coupling recombinant pyruvate decarboxylase and ω-transaminase. Appl. Microbiol. Biotechnol., 2014, 98: 7399-7408. (IF = 3.337)[9] Zhang J.L., Zhu T.Y., Wu X.R.*, Chen Y.J.* Enhancement of biocatalytic efficiency by increasing substrate loading: enzymatic preparation of L-homophenylalanine,Appl. Microbiol. Biotechnol.,2013, 97: 8487-8494. (IF = 3.337)

教育背景:

2011 年毕业于中国药科大学微生物与生化药学专业，获博士学位。