个人简述:

主要从事肿瘤及肝脏、肾脏纤维化的发生机制与治疗方法研究和干细胞促进组织损伤修复与再生的机制及应用研究。围绕结肠癌、肝癌、肝纤维化、肾纤维化等疾病展开深入研究，聚焦肿瘤早期炎瘤转变的发生过程和机制、肝纤维化的发生过程和机制、微生物与肿瘤及肝纤维化之间的关系等研究方向。提出了成体干细胞诱导与放化疗联合治疗肿瘤的新方案及利用成体干细胞治疗肝纤维化的新方案。

科研工作:

1. Wei-Jie Zhou, Zhen H. Geng, Jason R. Spence, and Jian-Guo Geng. (2013) Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection. Nature. 501:107-111. 2. Yuan Lin, Zhe-Ping Fang, Hong-Juan Liu, Li-Jing Wang, Zhiqiang Cheng, Na Tang, Tingting Li, Tengfei Liu, Hai-Xiong Han, Guangwen Cao, Li Liang, Yan-Qing Ding, Wei-Jie Zhou. (2017) HGFR-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells. Nature Communications. 8:1175. DOI: 10.1038s41467-017-01341-6. (corresponding author)3. Wei-Jie Zhou, Zhen H. Geng, Shan Chi, Wenli Zhang, Xiao-Feng Niu, Shu-Jue Lan, Li Ma, Xuesong Yang, Li-Jing Wang, Yan-Qing Ding, and Jian-Guo Geng. (2011) Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Research. 21(4):609-626.