个人简述:

蒋珺，女，博士，华南农业大学生命科学学院副研究员，硕士生导师。2009年毕业于中国科学院水生生物研究所，获遗传学博士学位。2009年-2011年，在华南农业大学生化与分子生物学系从事博士后工作，期间分别获得博士后科学基金面上资助和特别资助，并以高级研究助理身份赴香港李嘉诚医学院解剖学系进修。在博士后研究期间，首次揭示猪CYP3A46能催化T-2毒素发生3’-羟化反应。目前，主要从事猪、鸡细胞色素P450氧化酶（特别是参与T-2毒素代谢的细胞色素P450氧化酶）的功能、结构及表达调控机制研究。在蛋白表达纯化、酶动力学分析、启动子活性检测等方面有着丰富的研究经验。累积发表SCI论文21篇，其中第一作者论文7篇，累积影响因子超80。

科研工作:

科研项目
1.国家自然科学基金青年科学基金项目，No.31201716，2013.1-2015.12，21万，主持，在研

2.高等学校博士学科点专项科研基金新教师类，No.20124404120012，2013.1-2015.12，4万，主持，在研

3.广东省自然科学基金博士启动项目，No.S2012040007667，2012.10-2014.10，3万，主持，在研

4.中国博士后科学基金特别资助第4批，No.201104362，2011.4-2012.9，10万，主持，结题

5.中国博士后科学基金面上资助第47批，No.20100470930，2010.4-2011.9，3万，主持，结题

6.国家重点基础研究发展计划（973计划）子课题，No.2009CB118802，2009.1-2013.8，412万，参加（学术骨干），结题
发表论文
1.ShirleyM.H.Sy§,JunJiang§,WaiSumO,YiqunDeng,MichaelS.Y.Huen.2013.TheUbiquitinSpecificProteaseUSP34PromotesUbiquitinSignalingatDNADouble-StrandBreaks.NucleicAcidsResearch.41(18):8572-8580.(5-YrIF:8.055)(§co-firstauthor)

2.HuaCai§,JunJiang§,QiYang,QingmeiChen,YiqunDeng.2012.FunctionalCharacterizationofaFirstAvianCytochromeP450oftheCYP2DSubfamily(CYP2D49).PLoSOne.7(6):e38395.(5-YrIF:4.244)(§co-firstauthor)

3.JiansheWang§,JunJiang§,HongxiaZhang,JunpingWang,HuaCai,ChengLi,KangbaiLi,JingLiu,XuejiangGuo,GuangxunZou,DazhiWang,YiqunDeng,JiayinDai.2011.IntegratedtranscriptionalandproteomicanalysiswithinvitrobiochemicalassayrevealtheimportantroleofCYP3A46inT-2toxinhydroxylationinporcineprimaryhepatocytes.MolecularandCellularProteomics.10(9):10.1074/mcp.M111.008748,1-18.(5-YrIF:8.051)(§co-firstauthor)

4.ShirleyM.-H.Sy§,JunJiang§,Sui-suiDong,GabrielTsz-MeiLok,JunWu,HuaCai,EnochS.L.Yeung,JunHuang,JunjieChen,YiqunDeng,MichaelS.Y.Huen.2011.CriticalrolesofringfingerproteinRNF8inreplicationstressresponses.JournalofBiologicalChemistry.286(25):22355-22361.(5-YrIF:5.023)(§co-firstauthor)

5.JunJiang,JunpingWang,HuaCai,KangbaiLi,YiqunDeng.2011.CYP3Ascatalyzenifedipineoxidationinpiglivermicrosomes:enzymekinetics,inhibitionandfunctionalexpression.CatalysisCommunications.12(8):694-697.(5-YrIF:3.328)

6.JunJiang,Yi-BingZhang,ShunLi,Fei-FeiYu,FanSun,Jian-FangGui.2009.ExpressionregulationandfunctionalcharacterizationofanovelinterferoninduciblegeneGig2anditspromoter.MolecularImmunology.46(15):3131-3140.(5-YrIF:2.917)

7.Jian-HongXia§,JunJiang§,Yao-HuaShi,Jian-FangGui.2009.PredominantexpressionandcellulardistributionoffishAgr2inrenalcollectingsystem.ComparativeBiochemistryandPhysiologyPartB:BiochemistryandMolecularBiology.152(4):397-404.(5-YrIF:2.092)(§co-firstauthor)



8.FanSun,Yi-BingZhang,JunJiang,BingWang,ChenChen,JunZhang,Jian-FangGui.2014.Gig1,anovelantiviraleffectorinvolvedinfishinterferonresponse.Virology.448:322-332.(5-YrIF:3.164)

9.PeiqiangMu,MingXu,LeiZhang,KaixinWu,JunWu,JunJiang,QingmeiChen,LijuanWang,XianqingTang,YiqunDeng.2013.ProteomicchangesinchickenprimaryhepatocytesexposedtoT-2toxinareassociatedwithoxidativestressandmitochondrialenhancement.Proteomics.13(21):3175-3188.(5-YrIF:4.223)

10.ShufengShang,JunJiang,YiqunDeng.2013.ChickenCytochromeP4501A5istheKeyEnzymeforMetabolizingT-2Toxinto3'OH-T-2.InternationalJournalofMolecularSciences.14(6):10809-10818.(5-YrIF:2.732)

11.Yi-BingZhang,Ting-KaiLiu,JunJiang,JunShi,YingLiu,ShunLi,Jian-FangGui.2013.IdentificationofanovelGig2genefamilyspecifictonon-amniotevertebrates.PLoSOne.8(4):e60588.(5-YrIF:4.244)

12.JieChen,WanjuanFeng,JunJiang,YiqunDeng,MichaelS.Y.Huen.2012.RingFingerProteinRNF169AntagonisestheUbiquitin-DependentSignalingCascadeatSitesofDNADamage.JournalofBiologicalChemistry.287(33):27715-27722.(5-YrIF:5.023)

13.XianqingTang,PeiqiangMu,JunWu,JunJiang,CaihuiZhang,MingZheng,andYiqunDeng.2012.CarbonylReductionofMequindoxbyChickenandPorcineCytosolandClonedCBR1.DrugMetabolismandDisposition.40(4):788-795.(5-YrIF:3.678)

14.JingLiu,ManOuyang,JunJiang,PeiqiangMu,JunWu,QiYang,CaihuiZhang,WeiyingXu,LijuanWang,MichaelS.Y.Huen,YiqunDeng.2012.MequindoxinducedcellularDNAdamageviagenerationofreactiveoxygenspecies.MutationResearch-GeneticToxicologyandEnvironmentalMutagenesis.741(1-2):70-75.(5-YrIF:2.843)

15.MingZheng,JunJiang,JunpingWang,XianqingTang,ManOuyang,YiqunDeng.2011.TheMechanismofEnzymaticandNon-enzymaticN-oxideReductiveMetabolismofCyadoxinPigLiver.Xenobiotica.41(11):964–971.(5-YrIF:2.302)

16.JingLiu,XiaohuGe,ManOuyang,XianqingTang,JunWu,JunpingWang,JunJiang,MichaelS.Y.Huen,YiqunDeng.2011.CatalyticcharacteristicsofCYP3A22-dependentmequindoxdetoxification.CatalysisCommunications.12(7):637-643.(5-YrIF:3.382)

17.XiaohuGe,JunpingWang,JingLiu,JunJiang,HuinaLin,JunWu,ManOuyang,XianqingTang,MingZheng,MingLiao,YiqunDeng.2010.ThecatalyticactivityofcytochromeP4503A22iscriticalforthemetabolismofT-2toxininporcinereservoirs.CatalysisCommunications.12(2):71-75.(5-YrIF:3.382)

18.Fei-FeiYu,Yi-BingZhang,Ting-KaiLiu,YingLiu,FanSun,JunJiang,Jian-FangGui.2010.Fishvirus-inducedinterferonexertsantiviralfunctionthroughStat1pathway.MolecularImmunology.47(14):2330-2341.(5-YrIF:2.917)

19.YanShi,Yi-BingZhang,ZheZhao,JunJiang,Qi-YaZhang,Jian-FangGui.2008.MolecularcharacterizationandsubcellularlocalizationofCarassiusauratusinterferonregulatoryfactor-1.Developmental&ComparativeImmunology.32(2):134-146.(5-YrIF:3.4)

20.Yi-BingZhang,JunJiang,Yu-DongChen,RongZhu,YanShi,Qi-YaZhang,Jian-FangGui.2007.Theinnateimmuneresponsetograsscarphemorrhagicvirus(GCHV)inculturedCarassiusauratusblastulae(CAB)cells.Developmental&ComparativeImmunology.31(3):232-243.(5-YrIF:3.4)

21.Yu-DongChen,Yi-BingZhang,RongZhu,Fu-TieZhang,JunJiang,YanShi,Qi-YaZhang,Song-LinChen,Jian-FangGui.2005.InductiveexpressionandcharacterizationanalysisofParalichthysolivaceuspigmentepithelium-derivedfactorinavirallyinfectedcellline.BiochemicalandBiophysicalResearchCommunications.335(3):799-809.(5-YrIF:2.5)