个人简述:

杨静玉，女，博士，教授。1993年毕业于沈阳药科大学，1996年获得沈阳药科大学硕士学位，2000年获得沈阳药科大学博士学位，2002年被评为副教授、硕士生导师，2006年被评为教授、博士生导师。曾于1998-2000年赴日本东京大学留学。目前是药理学分科主席、临床药学专业负责人、生命科学与生物制药学院院长。所在课题组为是国家“十一五”重大新药创制综合平台辽宁省新药创制综合平台的重要组成部分，隶属于国家中医药局重点研究室、辽宁省新药筛选实验室、辽宁省新药药效评价重点实验室。作为负责人先后承担了国家自然科学基金（3项）、科技部“十一五”、“十二五”重大新药创制项目子项目等项目。已在NatureNanotechnololgy, Pharmacology Therapeutics, Journal of Neuroscience, Cancer Letter,Free Radical Biology Medicine, Oncotarget等期刊发表文章百余篇。

科研工作:

近年来发表代表性论文：1.Xue X1, Yang JY1, He Y1,Wang LR, Liu P, Yu LS, Bi GH, Zhu MM, Liu YY, Xiang RW, Yang XT, Fan XY, WangXM, Qi J, Zhan HJ, Wei T, Cui W, Ge GL, Xi ZX*, Wu CF*, Liang XJ*. Aggregatedsingle-walled carbon nanotubes attenuate the behavioural and neurochemicaleffects of methamphetamine in mice.Nature Nanotech, 2016,11(7):613-20.(IF=35.267)(News and ViewsNanomedicine: Going small to beat the high by Dr. Eric C. Peterson & LauraE. Ewing2.Yang JY*, Xue X, Tian H, Wang XX, Dong YX,Wang F, Zhao YN, Cui W, Wu CF*. Role of microglia in ethanol-inducedneurodegenerative disease: Pathological and behavioral dysfunction at differentdevelopmental stages. Pharmacol Ther. 2014,144(3):321-372. (IF=7.745)3.Wang LH, Chen GL, Chen K, Ren Y, Li HH, Jiang XR, Jia L, Fu SY, Li Y, Liu XW, Wang S, Yang JY*, WuCF*. Dualtargeting of retinoid X receptor and histone deacetylase with DW22 as a novelantitumor approach. Oncotarget,20156(12): 9740-9755. (IF=6.359)4.Zhu XN, Liu XD, Zhuang HY, Henkemeyer M, Yang JY*,Xu NJ*. Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation andInnate Fear.J Neurosci. 2016, 36(39): 10151–10162. (IF=5.98)5.Wang FY, Wang LH, ZhaoYF, Li Y,Ping GF, Xiao S, Chen K, Zhu WF, Gong P*, Yang JY*, Wu CF*. A novel small-molecule activator of procaspase-3induces apoptosis in cancer cells and reduces tumor growth in human breast,liver and gallbladder cancer xenografts. Mol Oncol. 2014, 8(8):1640-52. ( IF=5.935)6.Tian H, Ye XX,Hou XJ, Yang XW, Yang JY*, Wu CF*.SVCT2, a potential therapeutic target, protects against oxidative stress duringethanol-induced neurotoxicity via JNK/p38 MAPKs, NF-κB and miRNA125a-5p. Free Radical BioMed. 2016, 96:362-373. (IF=5.7367.Li Y , Fu SY, Wang LH, Wang FY,Wang NN, Cao Q, Wang Y T, Yang JY*, Wu CF* . Copper improves theanti-angiogenic activity of Disulfiram through the EGFR/Src/VEGF pathway ingliomas. Cancer Lett .2015369: 86-96. (IF=5.621)8.Liu P, Wu CF, Song W,Yu LS, Yang XF, Xiang RW, Wang F, YangJY*. Uridine decreases morphine-induced behavioral sensitization bydecreasing dorsal striatal dopamine release possibly via agonistic effects AtGABAA receptors. Eur Neuropsychopharmacol. 2014, 24(9):1557-66. (IF=5.395)9.Liu XW, Wang LH, Cui W,Yuan XZ, Lin LL, Cao Q, Wang NN, Li Y, Guo W, Zhang X, Wu CF*, Yang JY*. Targeting ALDH1A1 byDisulfiram/copper complex inhibits non-small cell lung cancer recurrence drivenby ALDH-positive cancer stem cells. Oncotarget, Epub 2016 Aug.(IF=5.008)10.WangXX, Wang CM, Wang JM, Zhao SQ, Zhang K, Zhang W, Wu CF*, Yang JY*.Pseudoginsesenoside-F11(PF11) exerts anti-neuroinflammatory effects onLPS-activated microglia cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKsand Akt signaling pathways. Neuropharmacology. 2014,79:642-656.(IF=4.819)