个人简述:

张经纬，药物科学研究院，博士，副研究员，硕士生导师。2006年毕业于中国药科大学基础药学理科基地班，获得学士学位。毕业时免试推荐至中国药科大学药物代谢动力学重点实验室直接攻读博士学位，师从王广基院士。博士毕业论文获2012年度江苏省优秀博士论文。博士毕业后留校工作，主要从事细胞药代动力学、分子药理学、中药/创新药物的药代动力学等研究工作，侧重于细胞药代动力学研究体系的建立及应用，药物代谢酶/转运体表达调控机制研究等。近几年来主持国家自然科学基金面上项目1项、国家自然科学基金青年基金1项、江苏省自然科学基金优秀青年基金1项、江苏省自然科学基金青年基金1项、教育部中央高校基本科研业务费专项资助（培育项目）1项，先后参加国家新药创制重大专项、国家自然科学基金重点项目、面上项目5项，同时负责多个横向课题研究。先后以第一作者/通讯作者发表SCI论文10篇。

科研工作:

主要研究成果：1. Liu J, Zhou F, Chen Q, Kang A, Lu M, Liu W, Zang X, Wang G*, Zhang J*. Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice. Sci Rep. 20155:13558. 2. Lu M, Zhou F, Hao K, Liu J, Chen Q, Ni P, Zhou H, Wang G*, Zhang J*. Alternation of adriamycin penetration kinetics in MCF-7 cells from 2D to 3D culture based on P-gp expression through the Chk2/p53/NF-κB pathway. Biochem Pharmacol. 201593(2):210-20.3. Jingwei Zhang, Jiali Liu, Yanlei Zhao, Guangji Wang*, and Fang Zhou*. Plasma and cellular pharmacokinetics considerations for the development and optimization of anti-tumor block copolymer micelles. Expert Opin Drug Deliv, 201512(2):263-814. Zhang J, Sun Y, Wang Y, Lu M, He J, Liu J, Chen Q, Zhang X, Zhou F*, Wang G*, Sun X. Non-antibiotic agent ginsenoside 20(S)-Rh2 enhanced the antibacterial effects of ciprofloxacin in vitro and in vivo as a potential NorA inhibitor. Eur J Pharmacol. 2014740:277-84.5. Jingwei Zhang, Meng Lu, Fang Zhou, Haopeng Sun, Gang Hao, Xiaolan Wu, Guangji Wang*. Key Role of Nf-κB in Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Synergistic Mechanism for 20(S)-Ginsenoside Rh2. Drug Metab Dispos, 2012,40(10):1900-86. Jingwei Zhang Fang Zhou Meng Lu Wei Ji Fang Niu Weibin Zha Xiaolan Wu Haiping Hao Guangji Wang*. Pharmacokinetics-Pharmacology Disconnection of Herbal Medicines and Its Potential Solutions with Cellular Pharmacokinetic-Pharmacodynamic Strategy. Current Drug Metab, 2012, 13(5):558-767. Jingwei Zhang Fang Zhou Fang Niu Meng Lu Xiaolan Wu Jianguo Sun Guangji Wang*. Stereoselective Regulations of P-glycoprotein by Ginsenoside Rh2 Epimers and the Potential Mechanisms From the View of Pharmacokinetics. Plos One, 2012, 7(4):e357688. Jingwei Zhang Fang Zhou Xiaolan Wu Xiaoxuan Zhang Yuancheng Chen BS Zha Fang Niu Meng Lu Gang Hao Yuan Sun Jianguo Sun Ying Peng Guangji Wang*. Cellular Pharmacokinetic Mechanisms of Adriamycin Resistance and Its Modulation by 20(S)-Ginsenoside Rh2 in MCF-7/Adr Cells. Br J Pharmacol, 2012, 165(1):120-1349. Jingwei Zhang Fang Zhou Xiaolan Wu Yi Gu Hua Ai Yuanting Zheng Yannan Li Xiaoxuan Zhang Gang Hao Jianguo Sun Ying Peng Guangji Wang*. 20(S)-Ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in viv a case for herb-drug interactions. Drug Metab Dispos, 2010, 38(12): 2179-2187