个人简述:

在研项目：
1.国家自然科学基金青年项目（主持人）：利用小分子p53-BH3功能模拟物研究Bcl-2-like/p53二聚体调控内源凋亡的分子机制，2016-2018

2.辽宁省博士启动基金（主持人），2016-2018

3.校际合作项目（主持人）：具有生物正交反应标记的糖基供体化学合成，2016-2017

发表论文：
1.LiuY,RenY,CaoY,etal.DiscoveryofaLowToxicityO-GlcNAcTransferase(OGT)InhibitorbyStructure-basedVirtualScreeningofNaturalProducts[J].ScientificReports,2017,7.

2.LiuY,HuangH,LiuM,etal.MicroRNA-24-1suppressesmousehepatomacellinvasionandmetastasisviadirectlytargetingO-GlcNActransferase[J].Biomedicine&Pharmacotherapy,2017,91:731-738.

3.LiuY,HuangH,CaoY,etal.SuppressionofOGTbymicroRNA24reducesFOXA1stabilityandpreventsbreastcancercellsinvasion[J].BiochemicalandBiophysicalResearchCommunications,2017,487(3):755-762.

4.YuboLiu,ZhichaoZhang,TingSong,FurongLiang,MingzhouXie,HongkunSheng.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.BritishJournalofPharmacology,169,1612-1623.

5.YuboLiu,ZhiqiangLi,TingSong,ZuguangXue,ZhichaoZhang.(2013)MechanismsofAnti-leukemicActivityoftheBcl-2HomologyDomain-3MimeticS1.Biomedicine&Pharmacotherapy,67,451-556.

6.YuboLiu，MingzhouXie，TingSong，HongkunSheng,XiaoyanYu,ZhichaoZhang.(2015)AnovelBH3mimeticefficientlyinducesapoptosisinmelanomacellsthroughdirectbindingtoanti-apoptoticBcl-2familyproteins，includingphosphorylatedMcl-1.PigmentCell&MelanomaResearch,28(2):161-170.

7.ZhichaoZhang,YuboLiu,TingSong,ZuguangXue,XiaoyunShen,FurongLiang,YanZhao,ZhiqiangLi,HongkunSheng.(2013)AnantiapoptoticBcl-2familyproteinindexpredictstheresponseofleukaemiccellstothepan-Bcl-2inhibitorS1.BritishJournalofcancer108,1870-1878.

8.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1innon-smallcelllungcancercellsthatphosphorylateBimthroughERK1/2andleadtoitsproteasomaldegradation.JournalofThoracicOncology,8,S1061.

9.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.JournalofThoracicOncology,2013,8,S767.

10.ZhichaoZhang,YanZhao,TingSong,YuboLiu,XiangqianLi,PengchenSu,ShenghuiXie.(2013)StudyofbindingthermodynamicsintheoptimizationofBH3mimetics.ChemicalBiology&DrugDesign,82,4,394-400.

11.TingSong,FurongLiang,ZhichaoZhang,YuboLiu,HongkunSheng,MingzhouXie.(2013)S1killsMCF-7/ADRcellsmorethanMCF-7cells:Aprotectivemechanismofendoplasmicreticulumstress.Biomedicine&Pharmacotherapy,67,451-556

12.TingSong,XilongChang,ZhichaoZhang,YuboLiu,XiaoyunShen.(2012)S1,aNovelPan-BH3Mimetic,InducesApoptosisinMcl-1-OverexpressingCellsThroughBak.JournalofPharmacologicalSciences119,330-340.

13.XingHuang,ChuangWang,SongLi,YuboLiu,ZhichaoZhang.(2014)HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.JournalofFluorescence.24(4),1313-1317.

14.YuboLiu,ZhichaoZhang.Ananti-apoptoticBcl-2familyproteinindexpredictstheresponseofleukemiccellstothepan-Bcl-2inhibitorS1.AACRAnnualMeeting2013.CancerResearch:2013,73,1710.

15.SongT,ChaiG,LiuY,etal.Bcl‐2phosphorylationconfersresistanceonchroniclymphocyticleukaemiacellstotheBH3mimeticsABT‐737,ABT‐263andABT‐199byimpedingdirectbinding[J].Britishjournalofpharmacology,2016,173(3):471-483.

16.Wang,A.,Song,T.,Wang,Z.,Liu,Y.,Fan,Y.,Zhang,Y.,&Zhang,Z.(2016).MechanismofMcl‐1ConformationalRegulationUponSmallMoleculeBindingRevealedbyMolecularDynamicSimulation.Chemicalbiology&drugdesign,87(4),551-561.

17.SongT,ChaiG,LiuY,etal.MechanismofsynergyofBH3mimeticsandpaclitaxelinchronicmyeloidleukemiacells:Mcl-1inhibition[J].EuropeanJournalofPharmaceuticalSciences,2015,70:64-71.

18.Huang,X.,Wang,C.,Li,S.,Liu,Y.,&Zhang,Z.(2014).HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.Journaloffluorescence,24(4),1313-1317.

19.李景煜，刘宇博，宋婷，沈晓云，张志超。（2012）BH3模拟物S1诱导人类白血病细胞株K562凋亡的作用机制。白血病·淋巴瘤2012年21卷第12期

20.邢欣荣，刘宇博，程智逵，伍会健（2008）组蛋白修饰酶对基因转录的调控.生理科学进展2008年第39卷第4期

科研工作:

在研项目：
1.国家自然科学基金青年项目（主持人）：利用小分子p53-BH3功能模拟物研究Bcl-2-like/p53二聚体调控内源凋亡的分子机制，2016-2018

2.辽宁省博士启动基金（主持人），2016-2018

3.校际合作项目（主持人）：具有生物正交反应标记的糖基供体化学合成，2016-2017

发表论文：
1.LiuY,RenY,CaoY,etal.DiscoveryofaLowToxicityO-GlcNAcTransferase(OGT)InhibitorbyStructure-basedVirtualScreeningofNaturalProducts[J].ScientificReports,2017,7.

2.LiuY,HuangH,LiuM,etal.MicroRNA-24-1suppressesmousehepatomacellinvasionandmetastasisviadirectlytargetingO-GlcNActransferase[J].Biomedicine&Pharmacotherapy,2017,91:731-738.

3.LiuY,HuangH,CaoY,etal.SuppressionofOGTbymicroRNA24reducesFOXA1stabilityandpreventsbreastcancercellsinvasion[J].BiochemicalandBiophysicalResearchCommunications,2017,487(3):755-762.

4.YuboLiu,ZhichaoZhang,TingSong,FurongLiang,MingzhouXie,HongkunSheng.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.BritishJournalofPharmacology,169,1612-1623.

5.YuboLiu,ZhiqiangLi,TingSong,ZuguangXue,ZhichaoZhang.(2013)MechanismsofAnti-leukemicActivityoftheBcl-2HomologyDomain-3MimeticS1.Biomedicine&Pharmacotherapy,67,451-556.

6.YuboLiu，MingzhouXie，TingSong，HongkunSheng,XiaoyanYu,ZhichaoZhang.(2015)AnovelBH3mimeticefficientlyinducesapoptosisinmelanomacellsthroughdirectbindingtoanti-apoptoticBcl-2familyproteins，includingphosphorylatedMcl-1.PigmentCell&MelanomaResearch,28(2):161-170.

7.ZhichaoZhang,YuboLiu,TingSong,ZuguangXue,XiaoyunShen,FurongLiang,YanZhao,ZhiqiangLi,HongkunSheng.(2013)AnantiapoptoticBcl-2familyproteinindexpredictstheresponseofleukaemiccellstothepan-Bcl-2inhibitorS1.BritishJournalofcancer108,1870-1878.

8.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1innon-smallcelllungcancercellsthatphosphorylateBimthroughERK1/2andleadtoitsproteasomaldegradation.JournalofThoracicOncology,8,S1061.

9.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.JournalofThoracicOncology,2013,8,S767.

10.ZhichaoZhang,YanZhao,TingSong,YuboLiu,XiangqianLi,PengchenSu,ShenghuiXie.(2013)StudyofbindingthermodynamicsintheoptimizationofBH3mimetics.ChemicalBiology&DrugDesign,82,4,394-400.

11.TingSong,FurongLiang,ZhichaoZhang,YuboLiu,HongkunSheng,MingzhouXie.(2013)S1killsMCF-7/ADRcellsmorethanMCF-7cells:Aprotectivemechanismofendoplasmicreticulumstress.Biomedicine&Pharmacotherapy,67,451-556

12.TingSong,XilongChang,ZhichaoZhang,YuboLiu,XiaoyunShen.(2012)S1,aNovelPan-BH3Mimetic,InducesApoptosisinMcl-1-OverexpressingCellsThroughBak.JournalofPharmacologicalSciences119,330-340.

13.XingHuang,ChuangWang,SongLi,YuboLiu,ZhichaoZhang.(2014)HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.JournalofFluorescence.24(4),1313-1317.

14.YuboLiu,ZhichaoZhang.Ananti-apoptoticBcl-2familyproteinindexpredictstheresponseofleukemiccellstothepan-Bcl-2inhibitorS1.AACRAnnualMeeting2013.CancerResearch:2013,73,1710.

15.SongT,ChaiG,LiuY,etal.Bcl‐2phosphorylationconfersresistanceonchroniclymphocyticleukaemiacellstotheBH3mimeticsABT‐737,ABT‐263andABT‐199byimpedingdirectbinding[J].Britishjournalofpharmacology,2016,173(3):471-483.

16.Wang,A.,Song,T.,Wang,Z.,Liu,Y.,Fan,Y.,Zhang,Y.,&Zhang,Z.(2016).MechanismofMcl‐1ConformationalRegulationUponSmallMoleculeBindingRevealedbyMolecularDynamicSimulation.Chemicalbiology&drugdesign,87(4),551-561.

17.SongT,ChaiG,LiuY,etal.MechanismofsynergyofBH3mimeticsandpaclitaxelinchronicmyeloidleukemiacells:Mcl-1inhibition[J].EuropeanJournalofPharmaceuticalSciences,2015,70:64-71.

18.Huang,X.,Wang,C.,Li,S.,Liu,Y.,&Zhang,Z.(2014).HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.Journaloffluorescence,24(4),1313-1317.

19.李景煜，刘宇博，宋婷，沈晓云，张志超。（2012）BH3模拟物S1诱导人类白血病细胞株K562凋亡的作用机制。白血病·淋巴瘤2012年21卷第12期

20.邢欣荣，刘宇博，程智逵，伍会健（2008）组蛋白修饰酶对基因转录的调控.生理科学进展2008年第39卷第4期

教育背景:

大连理工大学夜大学 电子