个人简述:

女，副教授。主讲的研究生课程有《现代制药工程实验》。已在JMC、JOC、DyesandPigments、AcsMed.Chem.Lett.Synthesis、BMC、BMCL、Tetrehedron、JFC、Chin.J.Chem.、Heterocycles、synth.Commun.、J.Heterocycl.Chem.等国际著名期刊上发表SCI论文30多篇，申请专利20多项，授权4项。在美国化学会国际大会、国际氟化学大会等会议上发表论文10多篇。累计主持国家级、省部级和校级研究项目20余项。

科研工作:

在研项目（2017年）（1）“高活性的、ROCK2/1亚型选择性的ROCK2抑制剂的设计与合成研究”，2016年国家自然基金，负责人。(2)‘“可再生燃料电池用一体化双功能催化剂的开发”，上海市科促会2016年联盟计划，负责人。(3)“3,3’-联二噻吩衍生物的合成及其应用研究”，2016年上海市分子催化和功能材料重点实验室研究基金，负责人。（4）“含氟Limk1抑制剂的设计、合成及应用研究”，2017年中国科学院有机氟化学重点实验室开放基金,负责人。（5）“基于“应用型”本科人才培养的《高分子材料基础》课程教学改革的探索与实践”，2015年上海应用技术学院校级教改项目，负责人。(6)“关于提高学术学位研究生创新能力的探索与实践”，2016年上海应用技术学院研究生教改项目，负责人。(7)“阿司匹林的制备及其质量控制”，2016年校企合作实验项目，负责人。(8)“大学生科创与制药工程专业应用型人才培养模式研究”，2016年上海应用技术大学高教课题，负责人。代表性论文（1）FengkaiCheng,YanYin*,GuozhenZhang,*,YuanWang,WeiDeng,FanhongWu“Optoelectronicandthermalpropertiesofhighlyfluorescenceemissive2,2’-distyryl-[3,3']-bithiophenes“Dyesandpigments2017,140,222-228(SCI,IF=4.0).（2）RuihongTao,YanYin*,YongbinDuan,YuxingSun,YueSun,FengkaiCheng,JinpengPan,ChenLu,YuanWangTetrahedron2017，10.1016/j.tet.2017.02.030（SCI,IF=2.6）(3)ZhaoZhao,JiaxinCui,YanYin,*HengZhang,YechengLiu,RuiZeng,ChaoFang,ZhenpengKai,ZhonghuaWang,*FanhongWua*“Synthesisandbiologicalevaluationofgem-difluoromethylenatedstatinderivativesashighlypotentHMG-CoAreductaseinhibitorsChin.J.Chem.2016,34,801-808(SCI,IF=1.9).(4)GuofengSun,FengkaiCheng,RuihengTao,YuxingSun,JinpengPang,Zhonghua,YaohuaZhu,ZhonghuaWang,FanhongWu,YanYin*“Superacid-catalyzedTandemMeyer-SchusterRearrangement/IntramolecularHydroaminationofo-AniliopropargyAlcoholstoSynthesize2,3-Dihydro-4(1H)-quinolones”Synth.Commun.2016,46,1249-1256(SCI,IF=1.0).(5)YanYin,KeZheng,NibalEid,ShannonHoward,Ji-HakJeong,FeiYi,JiaGuo,ChuiMinPark,MathieuBibian,WeilinWu,PamelaHernandez,HaJeungPark,YuntaoWu,Jun-LiLuo,PhilipV.Lograsso,YangboFeng“Bis-arylderivativesaspotentandselectiveLimkinaseinhinitors”J.Med.Chem.2015,58,1846-1861.(SCI,IF=5.6)(6)MeiDing,YanYin*,FanhongWu,JiaxingCui,HongZhou,GuofengSun,YuJiang,YangboFeng*“Discoveryofpotentandselectiveurea-basedROCKinhibitors:Exploringtheinhibitor’spotencyandROCK2/PKAselectivityby3D-QSAR,moleculardockingandmoleculardynamicssimulations”Bioorg.Med.Chem.2015,23,2505-2517(SCI,IF=2.9).(7)JiaxinCui,MeiDing,YanYin*,WeiDeng,ZhonghuaWang,YuJiang,HongZhou,GuofengSun,YangboFeng“Discoveryofbis-aryureaderivativesaspotentandselectiveLimkinhibitors:ExploringLimk1activityandLimk1/ROCK2selectivitythroughcomputationalstudies”Bioorg.Med.Chem.2015,23,7464-7477(SCI,IF=2.9)(8)YanYin*,HongZhou,XichenLiu,HaiyingChen,FanhongWu,HengZhang,RuihengTao,FengkaiCheng,YangboFeng“AMetal-FreeandRecyclableSynthesisofBenzothiazolesusingThioureaasaSulfurSurrogate”TetrahedronLett,2015,56,1709-1712.(SCI,IF=2.4)(9)YanYin*,HongZhou,GuofengSun,XichenLiu“m-CPBAMediatedIntramolecularAminohydroxylationofN-SulfonylAminoalkenestoSynthesizeβ-hydroxylCyclicAmines”JournalofHeterocyclicChemistry2015,1337-1345(SCI,IF=0.8)(10)YanYin*,Guo-FengSun,HengZhang,HongZhou,Fan-Hong,Wu“EnatioselectiveChalcogeno-Baylis-HillmanReactionofBenzaldehydeswithMVKandAcrylatesCatalyzedbyChiralThiepin-TiCl4Complex”Chin.J.Chem.2014,32,365-369.(SCI,IF=1.9)(11)YanYinLiLinClaudiaRuizSusanKhanMichaelDCameronWayneGrantJenniferPocasNibalEidHajeungParkThomasSchroeterPhilipV.LoGrassoYangboFeng“SynthesisandBiologicalEvaluationofUreaDerivativesasHighlyPotentandSelectiveRhoKinaseInhibitors”J.Med.Chem.2013,56,3568-3581。（SCI,IF=5.6）(12)YanYin,MichaelD.Cameron,LiLin,SusanKhan,ThomasSchrter,WayneGrant,JenniferPocas,YenTingChen,StephanSchrer,AlokPachori,PhilipLoGrasso*,YangboFeng*“DiscoveryofHighlyPotentandSelectiveUrea-basedROCKinhibitorsandtheireffectsontheintraocularpressureinrats”ACSMed.Chem.Lett.2010,1,175-179.(SCI,IF=3.2)(13)YanYin,LiLin,ClaudiaRuiz,MichaelD.Cameron,JenniferPocas,WayneGrant,ThomasSchrter,WeiminChen,DerekDuckett,StephanSchrer,PhilipLoGrasso,YangboFeng*“BenzothiazolesasRho-associatedkinase(ROCK-II)inhibitors”Bioorg.Med.Chem.Lett.2009,19,6686-6690.(SCI,IF=2.4)(14)YanYin,ZhuoChai,Wen-YingMa,GangZhao*“Synthesisofindolesviadiethylzinc-mediatedintramolecularhydroaminationreactionofalkynylsulfonamides”Synthesis2008,24,4036-4040.(15)YanYin,WenyingMa,ZhuoChai,GangZhao*“Et2Zn-CatalyzedIntramolecularHydroaminationofAminoalkynesandTandemCyclization/NucleophilicAdditionthroughtheIndoleZincSaltIntermediate”J.Org.Chem.2007,72,5731-5736.(16)YanYin,GangZhao*“HeptadecafluorooctanesulfonicAcid(C8F17SO3H)CatalyzedIntramolecularHydroaminationofOlefinicSulfonamidesinFluorousBiphaseSystem(FBS)”J.FluorineChem.2007,128,40-45.(17)YanYin,GangZhao*’”PerfluoroussuperacidC8F17SO3H-catalyzedintramolecularhydroaminationreactionofN-protected2-alkynylanilines:anovelsyntheticmethodforindoles”ChimicaOggi-ChemistryToday2007,25,42-45.(18)YanYin,GangZhao*“SynthesisofIndolinesandQuinolineviaCyclizationofN-Arylsulfonyl-2-allylanilinesCatalyzedbyBrnstedAcid”Heterocycles2006,68,23-31.

教育背景:

1998年本科毕业于四川大学化学系，2007年到美国的Emory大学进行博士后研究。