个人简述:

夏学锋，教授，博士生导师。美国TheMethodistHospitalResearchInstitute基因组医学中心（CenterforGenomicMedicine）和糖尿病研究中心(CenterforDiabetesResearch)的研究员（Scientist）。美国胃肠病协会(AGA)会员，美国肝脏病研究协会（AASLD）会员，美国内分泌学会（TheEndocrineSociety）会员。担任《Gastroenterology》、《Hepatology》、《Gut》、《AmericanJournalofPhysiology》、《AJP-GastrointestinalandLiverPhysiology》、《DigestiveandLiverDisease》等杂志审稿人。1998-2002年于美国贝勒医学院（BaylorCollegeofMedicine）完成PostdoctoralAssociate培训，曾担任德州大学休士顿医学院（UniversityofTexasHealthScienceCenteratHouston）医学系讲师(Instructor)和助理教授（AssistantProfessor）。已经培养博士研究生2名和博士后研究生8名。兰州大学萃英讲习教授和广州医学院特聘教授。主持完成课题9项，参与美国国立卫生研究所（NIH）项目5项，继续承担NIH课题和美国国防部课题2项，合作科研项目2项，发表ProcNatlAcadSciUSA,Cell,JClinInvest,Oncogene,CircRes,JBiolChem及Heptology有等高水平学术期刊论文40余篇，曾多次受邀在A&MUniversitySystemHealthScienceCenter、MDAndersonCancerCenter,UniversityofHouston、中南大学、广州医学院、华东师范大学、温州医学院、兰州大学及其他科研机构做专题报告，并多次参加国际会议交流并大会发言，论文获大会颁奖。2011年作为特邀嘉宾在东方内分泌-糖尿病论坛和中华内分泌年会大会报告。从事核激素受体（NuclearHormoneReceptor）在肿瘤、人体代谢，生殖内分泌调控，及肝胆疾病和肾脏疾病等领域的创新性研究，并取得卓著的成绩。

科研工作:

部分发表的论文： XiaX,JungD,WebbP,ZhangA,ZhangB,LiL,AyersSD,GabbieC,UenoY,GustafssoneJ,AlpiniG,MooreDD,LeSageGD. LiverXReceptorβandPeroxisomeProliferator-ActivatedReceptorδregulatecholesteroltransportincholangiocytes.    Hepatology. 2012Jun22.doi:10.1002/hep.25919.[Epubaheadofprint]YuB,LinH,YangL,ChenK,LuoH,LiuJ,GaoX,XiaX,HuangZ.GeneticvariationinNRF2-AREpathwayassociateswithdefectivespermatogenesisinhumans. JMolMed(Berl).2012May31.[Epubaheadofprint]WangF,YuB,YangW,LiuJ,LuJ,XiaX.Polycysticovarysyndromeresemblinghistopathologicalalterationsinovariesfromprenatalandrogenizedfemalerats. JOvarianRes.2012May185(1):15.[Epubaheadofprint]LiL,ZhangX,ZhaoL,XiaX,WangW.  ComparisonofDNAapoptosisinmouseandhumanblastocystsaftervitrificationandslowfreezing. MolReprodDev.2012Feb1,79:229?236 ZhouY,TozziF,ChenJ,FanF,XiaL,WangJ,GaoG,ZhangA,XiaX,BrasherH,WidgerW,EllisLM,WeihuaZ. IntracellularATPlevelsareapivotaldeterminantofchemoresistanceincoloncancercells. CancerRes.2012Jan172(1):304-14. SandulacheVC,SkinnerHD,OwTJ,ZhangA,XiaX,LuchakJM,WongLJ,PickeringCR,ZhouG,MyersJN.   Individualizinganti-metabolictreatmentstrategiesforheadandnecksquamouscellcarcinomabasedonTP53mutationalstatus. Cancer.2012Feb1118(3):711-21. DengT,SieglaffDH,ZhangA,LyonCJ,AyersSD,CvoroA,GupteAA,XiaX,BaxterJD,WebbP,HsuehWA.   Aperoxisomeproliferatoractivatedreceptor(PPAR)/PPARcoactivator1βautoregulatoryloopinadipocytemitochondrialfunction.JBiolChem.2011Sep2286(35):30723CollinsAR,LyonCJ,XiaX,LiuJZ,TangiralaRK,YinF,BoyadjianR,BikineyevaA,PraticòD,HarrisonDG,HsuehWA.Age-acceleratedatherosclerosiscorrelateswithfailuretoupregulateantioxidantgenes.CircRes.2009Mar27104(6):e42-54.ZhongX,LiuH,PuA,XiaX,ZhouX.Mcellsareinvolvedinpathogenesisofhumancontactlens-associatedgiantpapillaryconjunctivitis.ArchImmunolTherExp(Warsz).2007May55(3):173-7. ZhangW,XiaX,ReisenauerMR,VallonV,LangF,KuhlD,KoneBC.Aldosterone-inducedSGK1PhosphorylatesAF9andRelieves Dot1a-AF9-MediatedTranscriptionalRepressionofENaCalpha.  JClinInvest.2007Mar117(3):773-83. ZhangW,XiaX,ReisenauerMR,HemenwayCS,KoneBC.DOT1a-AF9complexmediateshistoneH3K79hypermethylationandrepressionofENaCαinanaldosterone-sensitivemanner. JBiolChem.2006Jun30281(26):18059-68. MaW,XiaX,StaffordLJ,YuC,WangF,LeSageG,LiuM.ExpressionofGCIPintransgenicmicedecreasessusceptibilitytochemicalhepatocarcinogenesis. Oncogene.2006Jul1325(30):4207-16.ZhangW,XiaX,JalalDI,KuncewiczT,XuW,LeSageGD,KoneBC.  Aldosterone-sensitiverepressionofENaCαtranscriptionbyahistoneH3lysine-79methyltransferase.AmJPhysiolCellPhysiol.2006Mar290(3):C936-46. AlpiniG,GlaserS,BaiocchiL,FrancisH,XiaX,LeSageG.   SecretinactivationoftheapicalNa(+)-dependentbileacidtransporterisassociatedwithcholehepaticshuntinginrats.  Hepatology.2005May41(5):1037-45.  YuZ,XiaX,KoneB. ExpressionProfileofaHumanInducibleNitricOxideSynthasePromoter-ReporterInTransgenicMiceDuringEndotoxemia. AmJPhysiolRenalPhysiol.2005Jan288(1):F214-20. XiaX,RoundtreeM,MerikhiA,LuX,ShentuS,LeSageG.  DegradationoftheApicalSodium-dependentBileAcidTransporter(ASBT)bytheUbiquitin-ProteasomePathwayinCholangiocytes. JBiolChem.2004279(43):44931-44937. ZhangW,XiaX,ZouL,XuX,LeSageGD,andKoneBC.  InVivoExpressionProfileofanH+-K+-ATPase2SubunitPromoter-reporterTransgene.      JPhysiolRenalPhysiol.2004Jun286(6):F1171-77. QyangY,ChambersSM,WangP,XiaX,ChenX,GoodellMA,ZhengH.  Myeloproliferativediseaseinmicewithreducedpresenilingenedosage:effectofgamma-secretaseblockage. Biochemistry.2004May1143(18):5352-9. KangDE,SorianoS,XiaX,EberhartCG,DeStrooperB,ZhengH,KooED.Presenilincouplesthepairedphosphorylationofbeta-cateninindependentofaxin:implicationsforbeta-cateninactivationintumorigenesis.  Cell.2002Sep20110(6):751-62.XiaX,WangP,SunX,SorianoS,ShumWK,YamaguchiH,TrumbauerME,TakashimaA,KooEH,ZhengH.Theaspartate-257ofpresenilin1isindispensableformousedevelopmentandproductionofbeta-amyloidpeptidesthroughbeta-catenin-independentmechanisms.ProcNatlAcadSciUSA.2002Jun2599(13):8760-5. MoehlmannT,WinklerE,XiaX,EdbauerD,MurrellJ,CapellA,KaetherC,ZhengH,GhettiB,HaassC,SteinerH.Presenilin-1mutationsofleucine166equallyaffectthegenerationoftheNotchandAPPintracellulardomainsindependentoftheireffectonAbeta42production.ProcNatlAcadSciUSA.2002Jun1199(12):8025-30. DineleyKT,XiaX,BuiD,SweattJD,ZhengH. Acceleratedplaqueaccumulation,associativelearningdeficits,andup-regulationofalpha7nicotinicreceptorproteinintransgenicmiceco-expressingmutanthumanpresenilin1andamyloidprecursorproteins. JBiolChem.2002Jun21277(25):22768-80. XiaX,QianS,SorianoS,WuY,FletcherAM,WangXJ,KooE,WuX,ZhengH.Lossofpresenilin1isassociatedwithenhancedbeta-cateninsignalingandskintumorigenesis.   ProcNatlAcadSciUSA.2001Sep1198(19):10863-8. Books,BookChaptersandReviews XiaX,FrancisH,GlaserS,AlpiniG,LeSageG.Bileacidinteractionswithcholangiocytes.WorldJGastroenterol.200612(22):3553-3563. XiaX,DeMorrowS,MarzioniM,FavaG,FrancisH,AlpiniG,GlaserS,LeSageG.CholangiocyteInjuryandDuctopenicSyndromes.SeminLiverDis.2007Nov27(4):401-12.XiaX,AlpiniG,LeSageG.   “ExtrahepatocyticTransportofBileAcids:TheRoleoftheCholangiocyte”.In:KepplerD,BeuersU,LeuschnerU,StiehlA,TraunerM,PaumgartnerG,eds.Bileacids:biologicalactionsandclinicalrelevance.ProceedingsoftheFalkSymposium1552006Oct6-7Freiberg(Germany).Dordrecht(TheNetherlands):Springer2007:71-75XiaX,LeSageG.,“Bileacidsandcholangiocytebiology”inPathophysiologyoftheIntrahepaticBiliaryEpithelium.  2008:ISBN:978-81-7895-337-3  TransworldResearchNetwork37/661(2),FortP.O.,Trivandrum-695023,Kerala,India   2009:1-20