个人简述:

吴丁兰，南方医科大学硕士研究生导师，南方医科大学深圳医院临床医学创新中心副研究员，深圳市海外高层次“孔雀计划”人才。于2012年在香港中文大学生物医学学院获得博士学位，并留任博士后、副研究员等工作，具有丰富的肿瘤学基础研究和转化医学研究经验。主要从事核受体与肿瘤发病机理、抗肿瘤治疗靶点和肿瘤免疫逃逸相关机制和转化医学研究。在BBA Reviews on Cancer, Oncogene, J Pathol等肿瘤学前沿杂志发表SCI学术论文近20篇。当前主持和承担国自然青年基金、面上基金、深圳市科技计划自由探索、学科布局等多项科研项目,在项经费300多万元。 研究方向1. 泌尿系统肿瘤发病机理和肿瘤标记物研发和转化研究研究方向2. 肿瘤免疫逃逸机制及肿瘤免疫治疗标记物研究研究方向3. 孤儿核受体TLX抗肿瘤靶向性研究

科研工作:

1. Wu D#, Cheung A#, Wang Y, Shan Yu, Chan FL. The emerging roles of orphan nuclear receptors in prostate cancer. BBA Reviews on Cancer.2016 Aug1866(1):23-36. (IF=9.452)2. Wu D, Yu S, Jia L, Zou C, Xu Z, Xiao L, Wong KB, Ng CF, Chan FL. Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of CDKN1A (p21WAF1CIP1) and SIRT1 genes. J Pathol. 2015 May236(1):103-15. (IF=7.429)3. Jia L #, Wu D#,*, Wang Y#, You W 1, Wang Z, Xiao L, Cai G, Xu Z, Zou C, Wang F, Ng C F, Yu S and Chan FL*. Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription.Oncogene. 2018 Jun37(25):3340-3355. (#共同一作*共同通讯，IF=8.559)4. Cai G#, Wu D#, Wang Z, Xu Z, Wong KB, Ng CF, Chan FL, Yu S. Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization. Oncogene .2017 Jan 2636(4):546-558.(#共同一作，IF=8.559)5. Wang Z#, Wu D#, Ng CF, Teoh JY, Yu S, Wang YL*, Chan FL*. Nuclear receptor profiling in prostatospheroids and castration-resistant prostate cancer. Endocr Relat Cancer. 2018,25:1,35-50. (#共同一作，IF=5.267)