个人简述:

殷菲，教授，硕士生导师。重庆市杰出青年基金获得者。2002.03–2005.06获得大连理工大学应用化学专业博士学位；1999.09–2002.01获重庆大学物理化学专业硕士学位；1993.09–1997.06获重庆大学精细化工专业学士学位。在国内外重要刊物如CNSNeurologicalDisorder-DrugTarget，PLOSONE，NeurochemistryInternational,NeuroscienceLetter,JournalofBiochemistry等发表论文38篇，其中SCI收录35篇，发表论文共被他人引用1000余次。

科研工作:

承担的主要项目

[1].京尼平苷皮层神经元中调节胰岛素降解酶基因表达调控的分子机制(81173063),国家自然科学基金,202.01-2015.12年,56万,主持。

[2].京尼平苷对海马神经元中Nrf2功能的调节机制及信号转导途径研究(30701020),国家自然科学基金,2008.01-2010.12年,24万,主持。

[3].京尼平苷对神经元葡萄糖吸收和代谢的调节剂作用机制研究(2014jcyjjq10003),重庆市杰出青年基金,2015.01-2017.12年，60万，主持。

[4].代谢性疾病药物药理，重庆市教委优秀创新团队，2016.09-2019.09，60万，主持。

[5].抗肿瘤药物增敏剂----三乙烯四胺的应用研究(CSTC,2008AC5028),重庆市科技攻关项目,2008.01-2010.12年,15万,主持。

[6].京尼平苷激活胰高血糖素样肽1受体调节胰岛素降解酶基因表达的分子机制研究(211148),教育部重点基础项目,2011.01-2013.12,10万,主持。

[7].京尼平苷调节Aβ代谢的分子机制,教育部回国人员科研启动基金,2012-2014年,3万,主持。

[8].京尼平苷调节糖尿病动物脑内β淀粉样蛋白代谢的分子机制研究(CSTC2013jjb10032),重庆市科技计划重点项目,2013-2014年,30万,主持。

1.ZhangYL,YinF*,LiuJH,LiuZX,ZidichouskiJ.GeniposideattenuatesthephosphorylationoftauproteinincellularandAPP/PS1transgenicmodelofAlzheimer’sdisease.ChemBiolDrugDes201687(3):409-18.

2.GuoLX,LiuCY,YinF*,LiuJH.PossibleroleofAMPK/SIRT1signalingonenergybalanceingeniposide-treatedINS-1cells.MedicinalChemistry201687(1):33-38

3.ZhangYL,LiuJH,LiuZX,YinF*.Geniposideattenuatedinsulin-deficiency-inducedaccelerationofβ-amyloidosisintheAPP/PS1transgenicmodelofAlzheimer’sdisease.NeurochemInt201589:7-16.

4.ZhangYL,XiaZN,LiuJH,LiuZX,YinF*.Cellsignalingtransductionmechanismsbywhichgeniposideregulatesinsulin-degradingenzymeexpressioninprimaryculturedcorticalneurons.CNSNeurologicalDisorders-DrugTargets201514(3):370-7.

5.LiuJH,LiuZX,ZhangYL,YinF*.LeptinsignalingplaysacriticalroleongeniposideamelioratingthephosphorylationoftauincellularandAPP/PS1transgenicmice.ActaBiochiBiophySin201547(12):1018-22.(IF=2.20)

6.LiuJH,LiuZX,ZhangYL,YinF*.Anovelantagonisticroleofnaturalcompoundicariinonneurotoxicityofamyloidβpeptide.IndianJournalMedRes2015142:190-195

7.ZhangYL,YinF,LiuJH*.GeniposideProtectspancreaticINS-1EβcellsfromhIAPP-inducedcelldamage:Potentialinvolvementofinsulindegradingenzyme.CellBiolInt201539(4):373-8.

8.LiuJH,ZhangYL,DengXH,YinF*.GeniposidedecreasesthelevelofAβ1-42inthebrainofstreptozotocin-induceddiabeticrats.ActaBiochimBiophySin201345(9):787-91.

9.LiuJH,GuoLX,YinF,ZhangYL,LiuZX,WangYW.GeniposideRegulatesGlucose-StimulatedInsulinSecretionPossiblythroughControllingGlucoseMetabolisminINS-1Cells.PLOSONE20138(10):e78315

10.YinF,ZhangYL,GuoLX,KongSZ,LiuJH.Geniposideregulatesinsulin-degradingenzymeexpressiontoinhibitthecytotoxicityofAβ1-42incorticalneurons.CNSNeurologicalDisorders-DrugTargets2012:11(8):1045-51.

11.GuoLX,LiuJH,YinF,GaoX.Regulationofinsulinsecretionbygeniposide:Possibleinvolvementofphosphatidylinositol3-phosphatekinase.EurRrevMedPharmaco201418(9):1287-1294.

12.LiuJH*,XiaoH,YinF,GuoLX,GaoX.Glucagon-likepeptide1receptorplaysanessentialroleingeniposideattenuatinglipotoxicity-inducedβ-cellapoptosisToxicologyinvitro201226(7):1093-7.

13.YinF,LiuJH,JiXH,WangYW,ZidichouskiJ,ZhangJZ.Silibinin:AnovelinhibitorofAβaggregation.NeurochemInt201158:399-403.

14.YinF,LiuJH,JiXH,WangYW,ZidichouskiJ,ZhangJZ.BaicalinpreventstheproductionofhydrogenperoxideandoxidativestressinducedbyAβaggregationinSH-SY5Ycells.NeurosciLett2011492(2):76-9.

15.YinF,LiuJH,ZhengXX,GuoLX,XiaoH.GeniposideinduestheexpressionofHO-1viaPI3K/Nrf2-signalingtoenhancetheantioxidantcapacityinprimaryhippocampalneurons.BiolPharmBull201033(11):1841-6.

16.YinF,LiuJH,ZhengXX,GuoLX.GLP-1receptorplaysacriticalroleingeniposideregulatingtheexpressionofhemeoxygenase-1inPC12cells.ActaPharmSin2010.31:540-5.

17.YinF,LiuJH,XiaoH,KongSZ.GeniposidepreventsPC12cellsfromperoxynitriteviaMAPkinasesignalpathway.JHealthSci.201056(2):195-199.

18.LiuJH,YinF,GuoLX,DengXH,HuYH.NeuroprotectionofgeniposideagainsthydrogenperoxideinducedPC12cellsinjury:InvolvementofPI3kinasesignalpathway.ActaPharmSin200930(2):159-65.

19.LiuJH,YinF,JingJJ,HuYH.Geniposide,anovelagonistforGLP-1receptor,preventsPC12cellsfromoxidativedamageviaMAPkinasepathway.NeurochemInt200751:361-9.

20.LiuJH,YinF,ZhengXX,HuYH,GuoLX,DengXH,ChenG,JingJJ,ZhangH.NeurotrophicpropertyofgeniposideforinducingtheneuronaldifferentiationofPC12Cells,IntJDevelopNeurosci200624(7):419-24.

21.YinF,DengXH,JingJJ.LiuJH*.EffectsoftriethylenetetraamineontheG-quadruplexstructureinthehumanc-Mycpromoter.JBiochem2007141:669-74.

22.GuoLX,YinF,JingJJ,LiuJH*.TriethylenetetraamineinducesthesenescenceofhumanbreastMCF-7cells.Biotechlett200830(1):47-53.

23.LiuJH,GuoLX,YinF,ZhengXX,ChenG,WangY.Characterizationandantitumoractivityoftriethylenetetramine,anoveltelomeraseinhibitor.BimedPharmcothera200862:480-5.

24.YinF,LiuJH,PengXJ.Triethylenetetraamine:Anoveltelomeraseinhibitor.BioorgMedChemLett200313(22):3923-6.

25.YinF,LiuJH,PengXJ.EffectoftriethylenetetraamineonthetelomeraseactivityandproliferationinHeLacells.CellBiolInt200428(4):287-91.