个人简述:

南方医科大学基础医学院免疫学教研室，教授，硕士生导师，博士生导师，博士后合作导师。近年来主要从事髓系抑制性细胞MDSC (myeloid-derived suppressor cells, MDSCs) 的分子调控机制及其临床应用价值的研究。具体包括：1. 新生个体 MDSC 的免疫调控机制及其在坏死性小肠炎（NEC）中的病理意义。我们研究发现新生儿MDSC可缓解新生儿坏死性小肠炎，但其机制尚未阐明。后期我们拟结合临床样本，对极低体重儿（易发NEC）样本的转录组分析，临床相关性分析以及分子机制研究，阐明MDSC缓解NEC的重要免疫学机制。以期为基于新生个体MDSC的免疫治疗提供新策略和新靶点。2. MDSC对妊娠并发症的调控机制及其病理意义。MDSC可诱导母胎耐受，但是MDSC在母胎耐受中的作用及诱导耐受的机制尚未阐明。我们拟通过临床样本解析MDSC调控母胎耐受的机制，并进一步分析MDSC对妊娠并发症的调控作用及病理意义。3. MDSC在炎症性疾病中的作用及病理意义。MDSC在自身免疫病中发挥重要作用。后期我们将系统研究MDSC对炎症性疾病的调控作用及其病理意义（肝炎，皮肌炎等）。以期为基于MDSC对炎症性疾病的细胞免疫治疗提供干预策略和靶标。

科研工作:

发表文章：1. Yu-Mei He#, Xing Li#, Michela Perego#, Yulia Nefedova, Andrew V. Kossenkov, Erik A. Jensen, Valerian Kagan, Yu-Feng Liu, Shu-Yu Fu, Qing-Jian Ye, Yan-Hong Zhou, Lai Wei, Dmitry I. Gabrilovich*, Jie Zhou*. Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation. Nature medicine (IF: 32.6). 2. Yumei He# Yan Chen Wen Song Lei Zhu Zhicheng Dong David W. Ow*. A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe. Nucleic Acids Research 2017 Jan 9 45(1):106-114. (IF: 11.6)3. Cao, Yingjiao# He, Yumei# Wang, Xiangyang Liu, Yongdong Shi, Kun Zheng Su, Xue Lei, Aihua He, Juan Zhou, Jie*. Polymorphonuclear myeloid-derived suppressor cells attenuate allergic airway inflammation by negatively regulating group 2 innate lymphoid cells. Immunology, 2018 Dec 21. doi: 10.1111imm.13040. [Epub ahead of print] (IF:3.7)4. Quan Yang#, Xing Li, Haiwen Chen, Yingjiao Cao, Yumei He, Jianyang Wei, Zhou, Jie*. IRF7 regulates the development of granulocytic myeloid-derived suppressor cells through S100A9 transrepression in cancer. Oncogene 2017 May 25 36 (21):2969-2980. (IF: 7.5)5. Nan J, Xing YF, Hu B, Tang JX, Dong HM, He YM, Ruan DY, Ye QJ, Cai JR, Ma XK, Chen J, Cai XR, Lin ZX, Wu XY, Li X. Endoplasmic reticulum stress induced LOX-1+ CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma. Immunology 2017 May154(1):144-155 (IF:4.1)6. Lei, Aihua# Yang, Qiong# Li, Xing Chen, Haiwen Shi, Maohua He, Yumei Zhou, Jie*. Atorvastatin promotes the expansion of myeloid-derived suppressor cells and attenuates murine colitis. Immunology 2016 Dec 149(4):432-446 (IF:4.1)7. Y M He#, KZ Xie* et al. Evolution of microbial community diversity and enzymatic activity during composting. Research in Microbiology 164 (2013) 189-198 (IF: 2.9).