个人简述:

王慧，女，中国药科大学副教授，硕士生导师，江苏省微生物学与免疫学会理事，江苏省“青蓝工程”优秀骨干教师，江苏省“六大人才高峰”第八批高层次人才。2008年毕业于南京医科大学，获免疫学博士学位。1999年获中山医科大学（中山大学中山医学院）免疫学硕士学位，1992年获徐州医学院临床医学学士学位。研究方向为生物学，目前主要从事抗肿瘤药物的研究，尤其是多糖类和多肽类抗肿瘤药物药效与机制的研究。近年来先后主持或参与国家科技重大专项、国家自然科学基金、教育部基金和江苏省科技计划项目等。目前发表学术论文40余篇，获得市级科技进步奖2项。长期从事本科生的《医学微生物学与免疫学》、《微生物学与免疫学》、《免疫学技术》等课程的教学工作，教学效果优秀，发表教学论文4篇，获得校级教学成果二等奖3项。

科研工作:

近三年代表性论文：1. Mengyun Ke1, Hui Wang1, Min Zhang, Yuwei Tian, Yizhou Wang, Bing Li, Jie Yu, Jie Dou, Changlin Zhou. The anti-lung cancer activity of SEP is mediated by the activation and cytotoxicity of NK cells via TLR2/4 in vivo. Biochemical Pharmacology.2014,89:119-130.2. Yuwei Tian1, Hui Wang1, Bing Li, Mengyun Ke, Jing Wang, Jie Dou, Changlin Zhou*. The cathelicidin-BF Lys16 mutant Cbf-K16 selectively inhibits non-small cell lung cancer proliferation in vitro. Oncology reports, 2013, 30:2502-2510.3. Hui Wang1 , Mengyun Ke1, Yuwei Tian, Jing Wang, Bing Li, Yizhou Wang, Jie Dou, Changlin Zhou*. BF-30 selectively inhibits melanoma cell proliferation via cytoplasmic membrane permeabilization and DNA-binding in vitro and in B16F10-bearing mice. European Journal of Pharmacology, 2013 (707) 1–10.4. Qingru Hao1, Hui Wang1, Jing Wang, Jie Dou, Min Zhang, Weidong Zhou, Changlin Zhou*. Effective antimicrobial activity of Cbf-K16 and Cbf-A7A13 against NDM-1-carrying Escherichia coli by DNA binding after penetrating the cytoplasmic membrane in vitro，Journal of Peptide science，2013, 19(3):173-180.5. Mengyu Wang 1, Hui Wang 1, Ying Tang, Di Kang, Mengyun Ke, Jie Dou, Tao Xi *, Changlin Zhou *，Effective inhibition of a Strongylocentrotus nudus eggs polysaccharide against hepatocellular carcinoma is mediated via immunoregulation in vivo. Immunology Letters, 2011 141(1):74-82.6. Wang H1, Wang MY1, Chen J1, Tang Y, Dou J, Yu J , Xi T *, Zhou CL *.A polysaccharide from Strongylocentrotus nudus eggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated mice. Int Immunopharmacol 201111(11):1946-1953.）