个人简述:

博士，副教授，生物制药专业硕士生导师。毕业于浙江大学，获生物化学和分子生物学专业博士学位，2014-2015年留学美国University of Texas Medical Branch (得克萨斯大学医学分部)，主要从事神经和细胞生物学及神经药理学研究。 承担国家863项目2项、国家科技支撑项目1项,主持浙江省自然科学基金项目、浙江省科技厅项目、浙江省教育厅项目、浙江省生物医学工程“重中之重”开放基金项目各1项。在Molecular Pharmaceutics等杂志发表SCI论文20余篇，申请国家发明专利3项，已授权1项，获得浙江省自然科学学术二等奖、三等奖各1项，为《British Journal of Medicine and Medical Research》等杂志审稿人。

科研工作:

我的研究成果

承担国家863项目2项、国家科技支撑项目1项。主持浙江省自然科学基金项目、浙江省科技厅项目、浙江省教育厅项目、浙江省生物医学工程“重中之重”开放基金项目各1项。发表论文20余篇，申请国家发明专利3项，已授权1项，获得浙江省自然科学学术二等奖、三等奖各1项，近五年发表SCI论文如下：

1. Zhang, W. Wang, J. Zhang, C. Fang, Q. Shu, J. Li, S. Jin, J. Wang, D. Nie, Z. Lv, Z. Zhang, Y. Synergetic Protein Factors That Improve rhGM-CSF Absorption via an Oral Route Exist in Silkworm Pupae. Molecular pharmaceutics 2015, 12, (5), 1347-55.

2. Zhang, W. Zhang, C. Lv, Z. Fang, D. Wang, D. Nie, Z. Yu, W. Lan, H. Jiang, C. Zhang, Y. Molecular characterization, tissue distribution, subcellular localization and actin-sequestering function of a thymosin protein from silkworm. PLoS One 2012, 7, (2), e31040.

3. Zhang, W. P. Lan, H. L. Wu, T. Jiang, C. Y. Lv, Z. B. Nie, Z. M. Wu, X. F. Zhang, Y. Z. Expression analysis and characteristics of hypothetical protein BmLOC778500 from silkworm, Bombyx mori. Afr J Biotechnol 2011, 10, (19), 3753-3761.

4. Zhang, W. Lv, Z. Nie, Z. Chen, G. Chen, J. Sheng, Q. Yu, W. Jin, Y. Wu, X. Zhang, Y. Bioavailability of orally administered rhGM-CSF: a single-dose, randomized, open-label, two-period crossover trial. PloS one 2009, 4, (5), e5353.

5. 张文平 杨久春 吕正兵 陶雷 张耀洲. 多肽和蛋白质药物口服吸收机制及策略的研究进展. 中国药理学与毒理学杂志 2013, 25, (5), 903-907.

6. 张文平，吕正兵，龙晓辉，聂作明，夏佳音，张耀洲. 家蚕孤雌生殖相关蛋白ＰＧＬ的鉴定与生物信息学分析. 蚕业科学 2010, 36, (6), 889-896.

7. Nie, Z. Zhou, F. Li, D. Lv, Z. Chen, J. Liu, Y. Shu, J. Sheng, Q. Yu, W. Zhang, W. Jiang, C. Yao, Y. Yao, J. Jin, Y. Zhang, Y. RIP-seq of BmAgo2-associated small RNAs reveal various types of small non-coding RNAs in the silkworm, Bombyx mori. BMC genomics 2013, 14, 661.

8. Liu, Y. Chen, Y. Chen, J. Zhang, W. Sheng, Q. Yu, W. Nie, Z. Zhang, Y. Wu, W. Wang, L. Indran, I. R. Li, J. Qian, L. Lv, Z. A shark liver gene-derived active peptide expressed in the silkworm, Bombyx mori: preliminary studies for oral administration of the recombinant protein. Marine drugs 2013, 11, (5), 1492-505.

9. Lv, Z. Wang, T. Zhuang, W. Wang, D. Chen, J. Nie, Z. Liu, L. Zhang, W. Wang, L. Wu, X. Li, J. Qian, L. Zhang, Y. The Expression, Purification, and Characterization of a Ras Oncogene (Bras2) in Silkworm (Bombyx mori). International journal of genomics 2013, 2013, 269609.

10. Lu, C. Zhang, J. Nie, Z. Chen, J. Zhang, W. Ren, X. Yu, W. Liu, L. Jiang, C. Zhang, Y. Guo, J. Wu, W. Shu, J. Lv, Z. Study of microRNAs related to the liver regeneration of the whitespotted bamboo shark, Chiloscyllium plagiosum. BioMed research international 2013, 2013, 795676.

11. Zhang, J. Liu, Y. Zhang, X. Pan, J. Nie, Z. Zhang, W. Yu, W. Chen, J. Liu, L. Li, J. Zhang, Y. Guo, J. Wu, W. Zhu, H. Lv, Z. The identification of microRNAs in the whitespotted bamboo shark (Chiloscyllium plagiosum) liver by Illumina sequencing. Gene 2013, 527, (1), 259-65.

12. Lv, Z. Zhang, X. Liu, L. Chen, J. Nie, Z. Sheng, Q. Zhang, W. Jiang, C. Yu, W. Wang, D. Wu, X. Zhang, S. Li, J. Zhang, Y. Characterization of a gene encoding prohibitin in silkworm, Bombyx mori. Gene 2012, 502, (2), 118-24.

13. Zhang, Y. Xia, Q. Xu, J. Chen, J. Nie, Z. Wang, D. Zhang, W. Zheng, Q. Chen, Q. Kong, L. Ren, X. Wang, J. Lv, Z. Yu, W. Jiang, C. Liu, L. Sheng, Q. Jin, Y. Wu, X. Aligning the proteome and genome of the silkworm, Bombyx mori. Functional & integrative genomics 2009, 9, (4), 447-54.

我的研究成果

2013年，获浙江省第五届“大学生生命科学学科竞赛”二等奖