科研工作:

近年主持科研课题主要有：1.国家自然科学基金项目：单细胞测序鉴定猪卵母细胞成熟和早期胚胎发育中的长链非编码RNA及其功能研究（31472098），2015-2018.2009-2013：近年参与完成的科研课题主要有：1.参加完成了美国农业部（USDA）课题“猪早期胚胎的microRNA表达及调控研究”和美国NIH课题“肌肉萎缩的转基因克隆猪模型的建立”（2008-35205-18712），2009-2013，(课题主持人：JasonWRoss)。2.参加完成了美国NIH资助的课题“美国NIH课题“肌肉萎缩的转基因克隆猪模型的建立”（RR-030232），2009-2013，(课题主持人：JasonWRoss)2.加者完成了一项中法合作交流项目，2004-2006。3.参加完成了两项973子课题“治疗性克隆灵长类动物模型的建立”和“克隆中线粒体命运的研究”，以及中科院重大专项研究“异种克隆大熊猫研究”，2001-2004，(课题主持人：陈大元)。近五年代表性著作、论文：1.HollingerK,YangCX,MontzRE,NonnemanD,RossJW,SelsbyJT.Dystrophininsufficiencycausesselectivemusclehistopathologyandlossofdystrophin-glycoproteincomplexassemblyinpigskeletalmuscle.FASEBJ.2013Dec17.2.HaleBJ,YangCX,RossJW.SmallRNAregulationofreproductivefunction.MolReprodDev.2013Oct24.doi:10.1002/mrd.22272.3.DuZQ⃰,YangCX⃰,RothschildMF,RossJW.NovelmicroRNAfamiliesexpandedinthehumangenome.BMCGenomics.2013Feb1214(1):98.(⃰Contributeequally)4.YangCX,LiuZ,FleurotR,AdenotP,DuranthonV,VignonX,ZhouQ,RenardJP,BeaujeanN.Heterochromatinreprogramminginrabbitembryosafterfertilization,intra-,andinter-speciesSCNTcorrelateswithpreimplantationdevelopment.Reproduction.2013,145(2):149-159.5.Cai-XiaYang,Zhi-QiangDuElaneCWright,MaxFRothschild,RandallS.Prather,andJasonW.Ross.SmallRNAprofileofthecumulus-oocytecomplexandearlyembryosinthepig.BiolReprod.2012Nov1687(5):117.YangCX,WrightEC,RossJW.ExpressionofRNA-bindingproteinsDND1andFXR1intheporcineovary,andduringoocytematurationandearlyembryodevelopment.MolReprodDev.2012,79(8):541-552.6.Cai-XiaYang,Zhao-HuiKou,KaiWang,YanJiang,Wen-WeiMao,Qing-YuanSun,Hui-ZhenSheng,Da-YuanChen.QuantitativeanalysisofmitochondrialDNAsinmacacaembryosreprogrammedbyrabbitoocytes.Reproduction.2004,127(2):201-205.7.Cai-XiaYang,Zhi-MingHan,Duan-ChengWen,Qing-YuanSun,Ke-YingZhang,Li-ShengZhang,Yu-QiWu,Zhao-HuiKou,Da-YuanChen.Invitrodevelopmentandmitochondrialfateofclonedmacaca-rabbitembryos.MolecularReproductionandDevelopment.2003,65(4):396-401.8.Duan-ChengWen,Cai-XiaYang,Zhong-HuaLiu,YongCheng,Qing-YuanSun,Jia-XinZhang,LeiLei,Yu-QiWu,Zhao-HuiKou,Da-YuanChen.Comparisonofdevelopmentalcapacitiesforintra-andinterspeciesclonedcat(Feliscatus)embryos.MolecularReproductionandDevelopment.2003,66(1):38-45.9.Man-XiJiang,Cai-XiaYang,Li-ShengZhang,Yue-LiangZheng,Shu-ZenLiu,Qing-YuanSunandDa-YuanChen.Theeffectsofchemicalenucleationcombinedwithwholecellintracytoplasmicinjectiononpanda-rabbitinterspeciesnucleartransfer.Zygote.2004,12(4):315-320.10.Man-XiJiang,Yue-LiangZheng,Shu-ZhenLiu,Cai-XiaYang,Li-ShengZhang,Ying-ChunOuyang,Qing-YuanSunandDa-YuanChen.Effectsofoocytecollectiontimeandinjectionpositiononpronucleusformationandblastocystdevelopmentinroundspermatidinjectionmouse.Zygote.2005,13(3):249-253.11.Duan-ChengWen,Chun-MingBi,YingXu,Cai-XiaYang,Zi-YuZhu,Qing-YuanSun,Da-YuanChen.HybridembryosproducedbytransferringpandaorcatsomaticnucleiintorabbitMIIoocytescandeveloptoblastocystinvitro.JExp.ZoologACompExpBiol.2005,303(8):689-697.12.Li-ShengZhang,Ke-YingZhang,Li-JuanYao,Shu-ZhenLiu,Cai-XiaYang,Zhi-ShengZhong,Yue-LiangZheng,Qing-YuanSun,Da-YuanChen.SomaticnucleusremodelinginimmatureandmatureRassiroocytecytoplasm.Zygote.2004,12(2):179-184.